That's a good question. The Ganglion uses 3.0V for it's analog supply AVDD.
the 'AGND' is generated by a voltage follower that outputs 1.5V (AVDD/2).
There are Instrumentation amplifiers on the front end that have a set gain of 51, so if you insert a signal into the Ganglion differential inputs that is 1V peak to peak in reference to AGND, then your signal will clip for sure.
Might be best to use a Voltage divider to drop the signal amplitude down to a level that won't clip? A rough calc would be 30mV peak to peak as absolute maximum, but it's untested and there are other things to consider.
biomurph: The AFE chip's AGND is Ganglion's GNDA which is Ganglion's ground. Maybe you were referring to D_G which a person could think of as analog ground for the patient.
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@biomurph may know!