My team is carrying on a research to record the electrical signal of cells, especially cardiac muscle cells or nuerons. We are very interested in Cyton Board and now posting to consult whether the Cyton Board is capable for the job.
Cyton and Ganglion are capable of all the common biosignals: EEG, EMG, ECG, EOG, etc. The signal amplitudes can range from the voltages of microvolts (EEG) to millivolts (ECG, EMG). The data is collected via a 'differential' amplifier that has both positive and negative input pins. The amp subtracts these two voltages to obtain the digitized sample output value.
In the case of EEG, one is not measuring individual neuron potentials, but the field effects of large ensembles of neurons, acting in synchrony.
Thank you for your help. I read about an article from Southeast University once, they cultivated a group of cardiac myocytes and successfully record the signal. They developed a micro-electrodes array and employed digital filtering for data acquisition and processing. Could we use Cyton to detect the signal from a single cell ?
@gs70rm said:
... They developed a micro-electrodes array and employed digital filtering for data acquisition and processing. Could we use Cyton to detect the signal from a single cell ?
I don't have any direct experience with recording from single cells. Other users here on the Forum may, but seems doubtful. The emphasis of OpenBCI is EEG, EMG, ECG, EOG, etc. It will all come down to the voltage produced by your cell, and if it can be measured with a differential electrode setup. If such a cell produces a millivolt to microvolt level signal, then yes it should work.
Are you aware of this organization? They have experience with neuronal spike recording.
Yes. We are considering about voltage and the setup of electrode arrays. Since team of SEU have already tested on a group of cells, it is posible that Cyton can apply to single cells. Though there is more obstruction like noise when it comes to single cells, right? I'm new to this field, so please correct me when I'm wrong.
Please re-read the previous comments. I have no direct experience with measuring single cells. I thought the Spikerbox info might give you clues. They seem to have success. If your signals are in millivolt range, OpenBCI is fine.
Comments
Hi Gs70rm,
Cyton and Ganglion are capable of all the common biosignals: EEG, EMG, ECG, EOG, etc. The signal amplitudes can range from the voltages of microvolts (EEG) to millivolts (ECG, EMG). The data is collected via a 'differential' amplifier that has both positive and negative input pins. The amp subtracts these two voltages to obtain the digitized sample output value.
In the case of EEG, one is not measuring individual neuron potentials, but the field effects of large ensembles of neurons, acting in synchrony.
William
Thank you for your help. I read about an article from Southeast University once, they cultivated a group of cardiac myocytes and successfully record the signal. They developed a micro-electrodes array and employed digital filtering for data acquisition and processing. Could we use Cyton to detect the signal from a single cell ?
I don't have any direct experience with recording from single cells. Other users here on the Forum may, but seems doubtful. The emphasis of OpenBCI is EEG, EMG, ECG, EOG, etc. It will all come down to the voltage produced by your cell, and if it can be measured with a differential electrode setup. If such a cell produces a millivolt to microvolt level signal, then yes it should work.
Are you aware of this organization? They have experience with neuronal spike recording.
https://backyardbrains.com/products/spikerbox
https://backyardbrains.com/experiments/
From this page it looks like signals are in the range of tens of millivolts,
https://backyardbrains.com/experiments/spikerbox
Remember, the OpenBCI boards operate 'differentially' with two pins for input, plus and minus. the amp subtracts these two voltage values.
William
Yes. We are considering about voltage and the setup of electrode arrays. Since team of SEU have already tested on a group of cells, it is posible that Cyton can apply to single cells. Though there is more obstruction like noise when it comes to single cells, right? I'm new to this field, so please correct me when I'm wrong.
Please re-read the previous comments. I have no direct experience with measuring single cells. I thought the Spikerbox info might give you clues. They seem to have success. If your signals are in millivolt range, OpenBCI is fine.